GLP-1 agonists, also known as glucagon-like peptide-1 receptor agonists, are a class of medications used treat type 2 diabetes and obesity. They work by mimicking the action of the naturally occurring hormone GLP-1. GLP-1 agonists have several beneficial effects on glucose metabolism:

1. Increased Insulin secretion: GLP-1 agonists enhance insulin secretion which helps to lower blood glucose levels after meals.

2. Slowing of Gastric Emptying: These medications slow down the rate at which the stomach empties which allows you to feel full for longer.

3. Increased Satiety: GLP-1 agonists act on your brain to reduce cravings and your overall appetite.

4. Cardiovascular Benefits: GLP-1 agonists (semaglutide) have recently been found to significantly reduce major adverse cardiovascular events (MACE) which includes heart attacks and strokes.

Examples of GLP-1 agonists include:

• Liraglutide (Saxenda)

• Semaglutide (Ozempic – approved for diabetes)

• Semaglutide (Wegovy – approved for obesity)

• Tirzepatide (Mounjaro – approved for diabetes) *

*works on GIP receptor as well

Berberine is a compound that is found in several plants, including goldenseal, barberry, and Oregon grape. It has been studied for its potential effects on various aspects of health, including weight loss and metabolic health. However, it's important to note that the research on berberine and weight loss is still evolving, and more studies are needed to fully understand its effects.